Isolated limb infusion as a model to test new agents to treat metastatic melanoma

Michael E. Lidsky; Paul J. Speicher; Betty Jiang; Masahito Tsutsui; Douglas S. Tyler

doi:10.1002/jso.23502

Isolated limb infusion as a model to test new agents to treat metastatic melanoma

Michael E. Lidsky, Paul J. Speicher, Betty Jiang, Masahito Tsutsui, Douglas S. Tyler

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-transit melanoma as a platform to investigate novel therapeutic approaches to improve regional disease control, and help us develop insights to more rationally design systemic therapy trials. J. Surg. Oncol. 2014 109:357-365.

Original language	English (US)
Pages (from-to)	357-365
Number of pages	9
Journal	Journal of Surgical Oncology
Volume	109
Issue number	4
DOIs	https://doi.org/10.1002/jso.23502
State	Published - Mar 2014
Externally published	Yes

Keywords

in-transit
isolated limb infusion
melanoma

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.23502

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title = "Isolated limb infusion as a model to test new agents to treat metastatic melanoma",

abstract = "The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-transit melanoma as a platform to investigate novel therapeutic approaches to improve regional disease control, and help us develop insights to more rationally design systemic therapy trials. J. Surg. Oncol. 2014 109:357-365.",

keywords = "in-transit, isolated limb infusion, melanoma",

author = "Lidsky, {Michael E.} and Speicher, {Paul J.} and Betty Jiang and Masahito Tsutsui and Tyler, {Douglas S.}",

year = "2014",

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T1 - Isolated limb infusion as a model to test new agents to treat metastatic melanoma

AU - Lidsky, Michael E.

AU - Speicher, Paul J.

AU - Jiang, Betty

AU - Tsutsui, Masahito

AU - Tyler, Douglas S.

PY - 2014/3

Y1 - 2014/3

N2 - The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-transit melanoma as a platform to investigate novel therapeutic approaches to improve regional disease control, and help us develop insights to more rationally design systemic therapy trials. J. Surg. Oncol. 2014 109:357-365.

AB - The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-transit melanoma as a platform to investigate novel therapeutic approaches to improve regional disease control, and help us develop insights to more rationally design systemic therapy trials. J. Surg. Oncol. 2014 109:357-365.

KW - in-transit

KW - isolated limb infusion

KW - melanoma

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JO - Journal of Surgical Oncology

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ER -

Isolated limb infusion as a model to test new agents to treat metastatic melanoma

Abstract

Keywords

ASJC Scopus subject areas

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