TY - JOUR
T1 - Isoantigen status in condyloma acuminata of the uterine cervix
T2 - An immunoperoxidase study
AU - Mambo, N. C.
PY - 1983
Y1 - 1983
N2 - The immunoperoxidase technique was used to investigate the blood isoantigen status in condyloma acuminata, which is regarded as being caused by the human papillomavirus (HPV). Since HPV is associated with epithelial atypias and intra-epithelial neoplasia, and since epithelial malignant transformation is associated with isoantigen loss, the purpose of the study was to determine if koilocytotic atypias are associated with isoantigen loss. Complete isoantigen loss was seen in 33% of cases, partial loss in 47%, and retention in 20%. The significance of this study lies in being able to recognize those lesions that may be associated with malignant transformation (80%) as indicated by isoantigen loss. Isoantigen retention may identify those epithelial atypias that undergo spontaneous regression. Long range follow-up of such patients will help further elucidate the role of HPV in neoplastic transformation of condylomatous lesions. The immunoperoxidase technique can be used in retrospective studies of condylomata of the cervix.
AB - The immunoperoxidase technique was used to investigate the blood isoantigen status in condyloma acuminata, which is regarded as being caused by the human papillomavirus (HPV). Since HPV is associated with epithelial atypias and intra-epithelial neoplasia, and since epithelial malignant transformation is associated with isoantigen loss, the purpose of the study was to determine if koilocytotic atypias are associated with isoantigen loss. Complete isoantigen loss was seen in 33% of cases, partial loss in 47%, and retention in 20%. The significance of this study lies in being able to recognize those lesions that may be associated with malignant transformation (80%) as indicated by isoantigen loss. Isoantigen retention may identify those epithelial atypias that undergo spontaneous regression. Long range follow-up of such patients will help further elucidate the role of HPV in neoplastic transformation of condylomatous lesions. The immunoperoxidase technique can be used in retrospective studies of condylomata of the cervix.
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U2 - 10.1093/ajcp/79.2.178
DO - 10.1093/ajcp/79.2.178
M3 - Article
C2 - 6297292
AN - SCOPUS:0020676368
SN - 0002-9173
VL - 79
SP - 178
EP - 181
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 2
ER -