Ischemic Hepatitis and Septic Shock Secondary to Murine Typhus Infection in Pregnancy

Marissa Berry, Amanda M. Wang, Rana F. Lahham, Xue Zhang, Luis D. Pacheco

Research output: Contribution to journalArticlepeer-review


Infection with murine typhus may be associated with significant morbidity. With nonspecific symptoms and laboratory abnormalities, diagnosis may be challenging. In this case, a pregnant patient presented with complaints of fevers and myalgias. Her laboratory results included severe transaminitis as well as thrombocytopenia and hyponatremia. She ultimately required vasopressor support and intensive care unit admission despite fluid resuscitation and broad-spectrum antibiotics. Empiric doxycycline was initiated due to suspicion for murine typhus, which laboratory testing later confirmed. Her clinical status improved with these interventions. This was a severe case of murine typhus resulting in septic shock and ischemic hepatitis. It is important to know the typical findings of murine typhus and consider it in a differential diagnosis, especially when practicing in endemic areas.

Original languageEnglish (US)
Pages (from-to)E185-E187
JournalAJP Reports
Issue number2
StatePublished - Jun 10 2024


  • ischemic hepatitis
  • murine typhus
  • septic shock

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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