Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions

Francisco A. Fernandez-Lima; Christopher Becker; Kent J. Gillig; William K. Russell; Shane E. Tichy; David H. Russell

doi:10.1021/ac801919n

Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions

Francisco A. Fernandez-Lima, Christopher Becker, Kent J. Gillig, William K. Russell, Shane E. Tichy, David H. Russell

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

An ion mobility-mass spectrometer (IM-MS) interface is described that can be employed to perform collisional activation and/or collision-induced dissociation (CID) with good transmission of mobility separated ions to the MS analyzer. The IM-MS interface consists of a stacked-ring ion guide design, where the field strength and pressure ratio can be operated such that structural rearrangement reactions and/or CID are achieved as a function of the effective ion temperature. The ion dynamics and collisional activation processes in the IM-MS interface are described as a function of the ion-neutral collisions, ion kinetic energies, and effective ion temperature. The applicability of the IM-CID-MS methodology to studies of peptide ion fragmentation is illustrated using a series of model peptides.

Original language	English (US)
Pages (from-to)	618-624
Number of pages	7
Journal	Analytical Chemistry
Volume	81
Issue number	2
DOIs	https://doi.org/10.1021/ac801919n
State	Published - Jan 15 2009
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry

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title = "Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions",

abstract = "An ion mobility-mass spectrometer (IM-MS) interface is described that can be employed to perform collisional activation and/or collision-induced dissociation (CID) with good transmission of mobility separated ions to the MS analyzer. The IM-MS interface consists of a stacked-ring ion guide design, where the field strength and pressure ratio can be operated such that structural rearrangement reactions and/or CID are achieved as a function of the effective ion temperature. The ion dynamics and collisional activation processes in the IM-MS interface are described as a function of the ion-neutral collisions, ion kinetic energies, and effective ion temperature. The applicability of the IM-CID-MS methodology to studies of peptide ion fragmentation is illustrated using a series of model peptides.",

author = "Fernandez-Lima, {Francisco A.} and Christopher Becker and Gillig, {Kent J.} and Russell, {William K.} and Tichy, {Shane E.} and Russell, {David H.}",

year = "2009",

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doi = "10.1021/ac801919n",

language = "English (US)",

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T1 - Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions

AU - Fernandez-Lima, Francisco A.

AU - Becker, Christopher

AU - Gillig, Kent J.

AU - Russell, William K.

AU - Tichy, Shane E.

AU - Russell, David H.

PY - 2009/1/15

Y1 - 2009/1/15

N2 - An ion mobility-mass spectrometer (IM-MS) interface is described that can be employed to perform collisional activation and/or collision-induced dissociation (CID) with good transmission of mobility separated ions to the MS analyzer. The IM-MS interface consists of a stacked-ring ion guide design, where the field strength and pressure ratio can be operated such that structural rearrangement reactions and/or CID are achieved as a function of the effective ion temperature. The ion dynamics and collisional activation processes in the IM-MS interface are described as a function of the ion-neutral collisions, ion kinetic energies, and effective ion temperature. The applicability of the IM-CID-MS methodology to studies of peptide ion fragmentation is illustrated using a series of model peptides.

AB - An ion mobility-mass spectrometer (IM-MS) interface is described that can be employed to perform collisional activation and/or collision-induced dissociation (CID) with good transmission of mobility separated ions to the MS analyzer. The IM-MS interface consists of a stacked-ring ion guide design, where the field strength and pressure ratio can be operated such that structural rearrangement reactions and/or CID are achieved as a function of the effective ion temperature. The ion dynamics and collisional activation processes in the IM-MS interface are described as a function of the ion-neutral collisions, ion kinetic energies, and effective ion temperature. The applicability of the IM-CID-MS methodology to studies of peptide ion fragmentation is illustrated using a series of model peptides.

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JO - Analytical Chemistry

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Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions

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