Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype

Carlos J. Montoya, Juan C. Cataño, Zoraida Ramirez, Maria T. Rugeles, S. Brian Wilson, Alan L. Landay

Research output: Contribution to journalArticlepeer-review

Abstract

The frequency, subsets and activation status of peripheral blood invariant NKT (iNKT) cells were evaluated in pulmonary tuberculosis (TB) patients and in chronically HIV-1-infected subjects. The absolute numbers of iNKT cells were significantly decreased in TB patients and in HIV-1+ individuals who were antiretroviral therapy naive or had detectable viremia despite receiving HAART. iNKT cell subset analysis demonstrated a decreased percentage of CD4+ iNKT cells in HIV-1+ subjects, and a decreased percentage of double negative iNKT cells in TB patients. Peripheral blood iNKT cells from HIV-1+ and TB patients had significantly increased expression of CD69, CD38, HLA-DR, CD16, CD56, and CD62L. The expression of CD25 was significantly increased only on iNKT cells from TB patients. These findings indicate that peripheral blood iNKT cells in these two chronic infections show an up-regulated expression of activation markers, suggesting their role in the immune response to infection.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalClinical Immunology
Volume127
Issue number1
DOIs
StatePublished - Apr 2008
Externally publishedYes

Keywords

  • Activation markers
  • HAART
  • HIV-1
  • Invariant NKT cells
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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