Interstitial Lung Diseases

Rodeo Abrencillo, Isabel C. Mira-Avendano, Rosa M. Estrada-Y-Martin, Irina Sadovnikov, Colin Zuchowski, Gokhan Kuyumcu, Anjali Taneja, Gabriel Duhancioglu, Usha Jayagurunathan, Matthew LeComte, Diana Palacio, Michelle Hershman, Patricia M. de Groot, Mylene T. Truong, Cesar A. Moran

Research output: Chapter in Book/Report/Conference proceedingChapter


Interstitial lung diseases (ILDs) comprise a heterogeneous group of complex chronic lung diseases. Patients with ILD present with progressive dyspnea, cough, and impaired pulmonary function resulting in quality of life issues. Mortality in patients with ILD can be as high as in some types of cancer. Patients with idiopathic pulmonary fibrosis (IPF), the most common of the idiopathic ILDs, have a median life expectancy of only 3–5 years from the time of diagnosis. Various ILD subtypes show overlap in pathophysiology and imaging appearance, which can confound ILD classification. Many experts conditionally agree that the reference standard for diagnostic decision-making and diagnosis of ILDs is through a multidisciplinary discussion including pulmonologist, radiologist, and pathologist. Multidisciplinary discussion of suspected IPF cases results in better interobserver agreement, better congruence, and higher confidence in the final diagnoses, and in certain cases, changes the impression to a non-IPF diagnosis. Multidisciplinary discussion also aids in making a decision to pursue invasive diagnostic procedures such as transbronchial biopsy, bronchoalveolar lavage, and surgical lung biopsy, especially when the risks of such procedures are high because of disease severity, advanced age, and comorbidities.

Original languageEnglish (US)
Title of host publicationThe Thorax
Subtitle of host publicationMedical, Radiological, and Pathological Assessment
PublisherSpringer International Publishing
Number of pages60
ISBN (Electronic)9783031210402
ISBN (Print)9783031210396
StatePublished - Jan 1 2023


  • Combined pulmonary fibrosis and emphysema
  • Connective tissue disorders
  • Desquamative interstitial pneumonia
  • Hypersensitivity pneumonitis
  • Idiopathic pulmonary fibrosis
  • Interstitial lung disease
  • Lymphangioleiomyomatosis
  • Nonspecific interstitial pneumonia
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • General Medicine


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