Interleukin-2 increases CD4+ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s

Hernan Valdez; Ronald Mitsuyasu; Alan Landay; Anne D. Sevin; Ellen S. Chan; John Spritzler; Spyros A. Kalams; Richard B. Pollard; John Fahey; Lawrence Fox; Ann Namkung; Scharla Estep; Ronald Moss; David Sahner; Michael M. Lederman

doi:10.1086/346056

Interleukin-2 increases CD4⁺ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s

Hernan Valdez, Ronald Mitsuyasu, Alan Landay, Anne D. Sevin, Ellen S. Chan, John Spritzler, Spyros A. Kalams, Richard B. Pollard, John Fahey, Lawrence Fox, Ann Namkung, Scharla Estep, Ronald Moss, David Sahner, Michael M. Lederman

Research output: Contribution to journal › Article › peer-review

Abstract

To ascertain whether CD4⁺ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4⁺ lymphocyte counts, IL-2 did not enhance immunization responses.

Original language	English (US)
Pages (from-to)	320-325
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	187
Issue number	2
DOIs	https://doi.org/10.1086/346056
State	Published - Jan 15 2003
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1086/346056

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Valdez, H., Mitsuyasu, R., Landay, A., Sevin, A. D., Chan, E. S., Spritzler, J., Kalams, S. A., Pollard, R. B., Fahey, J., Fox, L., Namkung, A., Estep, S., Moss, R., Sahner, D., & Lederman, M. M. (2003). Interleukin-2 increases CD4⁺ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s. Journal of Infectious Diseases, 187(2), 320-325. https://doi.org/10.1086/346056

Valdez, H, Mitsuyasu, R, Landay, A, Sevin, AD, Chan, ES, Spritzler, J, Kalams, SA, Pollard, RB, Fahey, J, Fox, L, Namkung, A, Estep, S, Moss, R, Sahner, D & Lederman, MM 2003, 'Interleukin-2 increases CD4⁺ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s', Journal of Infectious Diseases, vol. 187, no. 2, pp. 320-325. https://doi.org/10.1086/346056

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abstract = "To ascertain whether CD4+ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4+ lymphocyte counts, IL-2 did not enhance immunization responses.",

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AU - Valdez, Hernan

AU - Mitsuyasu, Ronald

AU - Landay, Alan

AU - Sevin, Anne D.

AU - Chan, Ellen S.

AU - Spritzler, John

AU - Kalams, Spyros A.

AU - Pollard, Richard B.

AU - Fahey, John

AU - Fox, Lawrence

AU - Namkung, Ann

AU - Estep, Scharla

AU - Moss, Ronald

AU - Sahner, David

AU - Lederman, Michael M.

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Interleukin-2 increases CD4⁺ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s

Abstract

ASJC Scopus subject areas

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