Interleukin-2 and autoimmune disease.

N. Talal, M. Dauphinée, P. Christadoss, G. Fernandes, I. J. Russell, N. Miyasaka, T. Nakamura

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)239-250
Number of pages12
JournalAdvances in nephrology from the Necker Hospital
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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