Interleukin-1-production by monocytes from patients with systemic lupus erythematosus

S. Sierakowski; E. J. Kucharz; R. W. Lightfoot; J. S. Goodwin

doi:10.1007/BF02206840

Interleukin-1-production by monocytes from patients with systemic lupus erythematosus

S. Sierakowski, E. J. Kucharz, R. W. Lightfoot, J. S. Goodwin

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 μg of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.

Original language	English (US)
Pages (from-to)	403-407
Number of pages	5
Journal	Clinical Rheumatology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1007/BF02206840
State	Published - Sep 1987
Externally published	Yes

Keywords

Interleukin-1
Monocytes
Systemic Lupus Erythematosus

ASJC Scopus subject areas

Rheumatology

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10.1007/BF02206840

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title = "Interleukin-1-production by monocytes from patients with systemic lupus erythematosus",

abstract = "Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 μg of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.",

keywords = "Interleukin-1, Monocytes, Systemic Lupus Erythematosus",

author = "S. Sierakowski and Kucharz, {E. J.} and Lightfoot, {R. W.} and Goodwin, {J. S.}",

year = "1987",

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T1 - Interleukin-1-production by monocytes from patients with systemic lupus erythematosus

AU - Sierakowski, S.

AU - Kucharz, E. J.

AU - Lightfoot, R. W.

AU - Goodwin, J. S.

PY - 1987/9

Y1 - 1987/9

N2 - Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 μg of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.

AB - Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 μg of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.

KW - Interleukin-1

KW - Monocytes

KW - Systemic Lupus Erythematosus

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Interleukin-1-production by monocytes from patients with systemic lupus erythematosus

Abstract

Keywords

ASJC Scopus subject areas

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