Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice

Tian Wang; Mustafa Akkoyunlu; Rila Banerjee; Erol Fikrig

doi:10.1016/j.femsim.2004.06.001

Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice

Tian Wang, Mustafa Akkoyunlu, Rila Banerjee, Erol Fikrig

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Immunocompetent mice 129Sv (129) and C57BL/6 (B6) mice are similarly susceptible to Anaplasma phagocytophilum. We now show that 129 mice lacking interferon-γ (IFN-γ) develop more severe infection with A. phagocytophilum than IFN-γ deficient B6 mice. These data demonstrate that there is an inherent increased susceptibility of 129 mice, compared with B6 mice, to A. phagocytophilum that can only be discerned in the absence of IFN-γ.

Original language	English (US)
Pages (from-to)	299-305
Number of pages	7
Journal	FEMS Immunology and Medical Microbiology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1016/j.femsim.2004.06.001
State	Published - Nov 1 2004
Externally published	Yes

Keywords

Animal mode
Ehrlichiosis
Interferon-γ
Tick

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

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10.1016/j.femsim.2004.06.001

Cite this

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title = "Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice",

abstract = "Immunocompetent mice 129Sv (129) and C57BL/6 (B6) mice are similarly susceptible to Anaplasma phagocytophilum. We now show that 129 mice lacking interferon-γ (IFN-γ) develop more severe infection with A. phagocytophilum than IFN-γ deficient B6 mice. These data demonstrate that there is an inherent increased susceptibility of 129 mice, compared with B6 mice, to A. phagocytophilum that can only be discerned in the absence of IFN-γ.",

keywords = "Animal mode, Ehrlichiosis, Interferon-γ, Tick",

author = "Tian Wang and Mustafa Akkoyunlu and Rila Banerjee and Erol Fikrig",

note = "Funding Information: This work was supported by grants from the NIH grant, the Burroughs Wellcome Fund and a J. Kempner Postdoctoral Fellowship. We thank Debbie Beck for technical assistance and Eduardo Cantin for providing genetically deficient mice.",

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doi = "10.1016/j.femsim.2004.06.001",

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AU - Wang, Tian

AU - Akkoyunlu, Mustafa

AU - Banerjee, Rila

AU - Fikrig, Erol

N1 - Funding Information: This work was supported by grants from the NIH grant, the Burroughs Wellcome Fund and a J. Kempner Postdoctoral Fellowship. We thank Debbie Beck for technical assistance and Eduardo Cantin for providing genetically deficient mice.

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Y1 - 2004/11/1

N2 - Immunocompetent mice 129Sv (129) and C57BL/6 (B6) mice are similarly susceptible to Anaplasma phagocytophilum. We now show that 129 mice lacking interferon-γ (IFN-γ) develop more severe infection with A. phagocytophilum than IFN-γ deficient B6 mice. These data demonstrate that there is an inherent increased susceptibility of 129 mice, compared with B6 mice, to A. phagocytophilum that can only be discerned in the absence of IFN-γ.

AB - Immunocompetent mice 129Sv (129) and C57BL/6 (B6) mice are similarly susceptible to Anaplasma phagocytophilum. We now show that 129 mice lacking interferon-γ (IFN-γ) develop more severe infection with A. phagocytophilum than IFN-γ deficient B6 mice. These data demonstrate that there is an inherent increased susceptibility of 129 mice, compared with B6 mice, to A. phagocytophilum that can only be discerned in the absence of IFN-γ.

KW - Animal mode

KW - Ehrlichiosis

KW - Interferon-γ

KW - Tick

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Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice

Abstract

Keywords

ASJC Scopus subject areas

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