interaction of silica with plasma proteins: In vivo studies

Shivendra V. Singh; M. F. Khan; Q. Rahman

doi:10.1016/0378-4274(85)90014-1

interaction of silica with plasma proteins: In vivo studies

Shivendra V. Singh, M. F. Khan, Q. Rahman

Research output: Contribution to journal › Article › peer-review

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Abstract

Silicic acid has been shown to be the main pathogenic factor in the toxicity of silicate dusts. Our earlier findings have shown the interaction of silica (silicic acid) with rat plasma and lung proteins in vitro. In the present communication, we report the binding of silica with plasma protein in vivo. The significance of in vivo silica-protein interaction is discussed in relation to its toxicity and clearance from the body.

Original language	English (US)
Pages (from-to)	89-92
Number of pages	4
Journal	Toxicology Letters
Volume	28
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-4274(85)90014-1
State	Published - Nov 1985
Externally published	Yes

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(85)90014-1

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title = "interaction of silica with plasma proteins: In vivo studies",

abstract = "Silicic acid has been shown to be the main pathogenic factor in the toxicity of silicate dusts. Our earlier findings have shown the interaction of silica (silicic acid) with rat plasma and lung proteins in vitro. In the present communication, we report the binding of silica with plasma protein in vivo. The significance of in vivo silica-protein interaction is discussed in relation to its toxicity and clearance from the body.",

author = "Singh, {Shivendra V.} and Khan, {M. F.} and Q. Rahman",

note = "Funding Information: The authors are thankful to Dr. C.R. Krishna Murti, former Director ITRC, for his valuable suggestions. Supported in part by EPA grant PRI 503.2.",

year = "1985",

month = nov,

doi = "10.1016/0378-4274(85)90014-1",

language = "English (US)",

volume = "28",

pages = "89--92",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

number = "2-3",

}

TY - JOUR

T1 - interaction of silica with plasma proteins

T2 - In vivo studies

AU - Singh, Shivendra V.

AU - Khan, M. F.

AU - Rahman, Q.

N1 - Funding Information: The authors are thankful to Dr. C.R. Krishna Murti, former Director ITRC, for his valuable suggestions. Supported in part by EPA grant PRI 503.2.

PY - 1985/11

Y1 - 1985/11

N2 - Silicic acid has been shown to be the main pathogenic factor in the toxicity of silicate dusts. Our earlier findings have shown the interaction of silica (silicic acid) with rat plasma and lung proteins in vitro. In the present communication, we report the binding of silica with plasma protein in vivo. The significance of in vivo silica-protein interaction is discussed in relation to its toxicity and clearance from the body.

AB - Silicic acid has been shown to be the main pathogenic factor in the toxicity of silicate dusts. Our earlier findings have shown the interaction of silica (silicic acid) with rat plasma and lung proteins in vitro. In the present communication, we report the binding of silica with plasma protein in vivo. The significance of in vivo silica-protein interaction is discussed in relation to its toxicity and clearance from the body.

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U2 - 10.1016/0378-4274(85)90014-1

DO - 10.1016/0378-4274(85)90014-1

M3 - Article

C2 - 3000029

AN - SCOPUS:0022354684

SN - 0378-4274

VL - 28

SP - 89

EP - 92

JO - Toxicology Letters

JF - Toxicology Letters

IS - 2-3

ER -

interaction of silica with plasma proteins: In vivo studies

Abstract

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