Interaction between blood flow and motility in normal and inflamed ileum

V. E. Cowles, R. P. Ryan, S. K. Sarna

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The alterations in local and superior mesenteric blood flow during ileal inflammation and their correlations with motility in the normal and the inflamed ileum were investigated in the conscious state. Ileal inflammation decreased the local mesenteric blood flow but had no significant effect on the superior mesenteric blood flow. A significant reduction or an increase in local mesenteric blood flow in the normal or the inflamed ileum had no effect on local contractile activity. The vascular reactivity to vaso-dilators and vaso-constrictors was significantly reduced during inflammation. Local mesenteric blood flow increased significantly in the descending segment ahead of a caudal propagating giant migrating contraction. The local mesenteric blood flow oscillated during a migrating motor complex (MMC) cycle. We conclude that a several-fold increase or decrease in local mesenteric blood flow lasting for several minutes does not affect contractility. Ileal inflammation decreases local mesenteric blood flow but does not affect the total blood flow to the small intestine.

Original languageEnglish (US)
Pages (from-to)409-420
Number of pages12
JournalNeurogastroenterology and Motility
Issue number6
StatePublished - 1999
Externally publishedYes


  • Angiotensin II
  • Inflammation
  • Motility
  • Phentolamine
  • Vascular reactivity

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology


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