Insulinotropic and gastrin-releasing action of gastrin-releasing peptide (GRP)

George H. Greeley; James C. Thompson

doi:10.1016/0167-0115(84)90164-2

Insulinotropic and gastrin-releasing action of gastrin-releasing peptide (GRP)

George H. Greeley, James C. Thompson

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The effect of intravenous administration of gastrin-releasing peptide (GRP) on serum gastrin and insulin levels was studied in ad libitum fed and 24-h fasted rats. Administration of GRP (55 μg/kg body weight) caused a significant (P < 0.05) elevation in serum gastrin levels at 10, 30, 60, and 120 min in the rats fed ad libitum, whereas in the fasted rats, gastrin levels rose significantly only at 10 min. GRP did not cause insulin release in fasted rats, but in the fed rats, it led to a significant elevation in serum insulin levels at 10 and 30 min, in comparison to controls. GRP appears to have an insulinotropic action in addition to a gastrin-releasing effect.

Original language	English (US)
Pages (from-to)	97-103
Number of pages	7
Journal	Regulatory Peptides
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/0167-0115(84)90164-2
State	Published - Mar 1984
Externally published	Yes

Keywords

GRP
fasted rats
fed rats
gastrin
insulin

ASJC Scopus subject areas

Endocrinology
Cellular and Molecular Neuroscience
Physiology
Biochemistry
Clinical Biochemistry

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10.1016/0167-0115(84)90164-2

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title = "Insulinotropic and gastrin-releasing action of gastrin-releasing peptide (GRP)",

abstract = "The effect of intravenous administration of gastrin-releasing peptide (GRP) on serum gastrin and insulin levels was studied in ad libitum fed and 24-h fasted rats. Administration of GRP (55 μg/kg body weight) caused a significant (P < 0.05) elevation in serum gastrin levels at 10, 30, 60, and 120 min in the rats fed ad libitum, whereas in the fasted rats, gastrin levels rose significantly only at 10 min. GRP did not cause insulin release in fasted rats, but in the fed rats, it led to a significant elevation in serum insulin levels at 10 and 30 min, in comparison to controls. GRP appears to have an insulinotropic action in addition to a gastrin-releasing effect.",

keywords = "GRP, fasted rats, fed rats, gastrin, insulin",

author = "Greeley, {George H.} and Thompson, {James C.}",

note = "Funding Information: * Supported by a grant from the National Institutes of Health (AM 15241). Address correspondence to: George H. Greeley, Jr., Ph.D., Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A: Telephone: (409) 761o2094.",

year = "1984",

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AU - Greeley, George H.

AU - Thompson, James C.

N1 - Funding Information: * Supported by a grant from the National Institutes of Health (AM 15241). Address correspondence to: George H. Greeley, Jr., Ph.D., Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A: Telephone: (409) 761o2094.

PY - 1984/3

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N2 - The effect of intravenous administration of gastrin-releasing peptide (GRP) on serum gastrin and insulin levels was studied in ad libitum fed and 24-h fasted rats. Administration of GRP (55 μg/kg body weight) caused a significant (P < 0.05) elevation in serum gastrin levels at 10, 30, 60, and 120 min in the rats fed ad libitum, whereas in the fasted rats, gastrin levels rose significantly only at 10 min. GRP did not cause insulin release in fasted rats, but in the fed rats, it led to a significant elevation in serum insulin levels at 10 and 30 min, in comparison to controls. GRP appears to have an insulinotropic action in addition to a gastrin-releasing effect.

AB - The effect of intravenous administration of gastrin-releasing peptide (GRP) on serum gastrin and insulin levels was studied in ad libitum fed and 24-h fasted rats. Administration of GRP (55 μg/kg body weight) caused a significant (P < 0.05) elevation in serum gastrin levels at 10, 30, 60, and 120 min in the rats fed ad libitum, whereas in the fasted rats, gastrin levels rose significantly only at 10 min. GRP did not cause insulin release in fasted rats, but in the fed rats, it led to a significant elevation in serum insulin levels at 10 and 30 min, in comparison to controls. GRP appears to have an insulinotropic action in addition to a gastrin-releasing effect.

KW - GRP

KW - fasted rats

KW - fed rats

KW - gastrin

KW - insulin

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Insulinotropic and gastrin-releasing action of gastrin-releasing peptide (GRP)

Abstract

Keywords

ASJC Scopus subject areas

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