Insulin-like Growth Factor-I et dénutrition aiguë ou chronique

Malnutrition is a common problem affecting many patients with both acute and chronic illnesses. Nutrient delivery via patenteral or enteral routes has alleviated some of the problems that arise from well defined nutritional deficiencies. However, it has made a much smaller impact on wasting associated with illness. Modulation of metabolism with exogenous agents is attractive as a means to improve outcomes in patients that are susceptible to wasting. Insulin-like Growth Factor-I (IGF-I) and Growth Hormone (GH) are hormones that can be used for this purpose, and may have widespread clinical utility to improve wound healing, maintain lean body mass, and preserve organ function. Studies are ongoing to elucidate the possible benefits of these agents.