TY - JOUR
T1 - Innate immune response to arenaviral infection
T2 - A focus on the highly pathogenic new world hemorrhagic arenaviruses
AU - Koma, Takaaki
AU - Huang, Cheng
AU - Kolokoltsova, Olga A.
AU - Brasier, Allan R.
AU - Paessler, Slobodan
N1 - Funding Information:
The authors' research is supported by Public Health Service grant R01AI093445 to S.P. T.K. is supported by the Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists program. O.K. is supported by the Sealy Center for Vaccine Development pre-doctoral fellowship, University of Texas Medical Branch.
PY - 2013/12/13
Y1 - 2013/12/13
N2 - Arenaviruses are enveloped, negative-stranded RNA viruses that belong to the family Arenaviridae. This diverse family can be further classified into OW (Old World) and NW (New World) arenaviruses based on their antigenicity, phylogeny, and geographical distribution. Many of the NW arenaviruses are highly pathogenic viruses that cause systemic human infections characterized by hemorrhagic fever and/or neurological manifestations, constituting public health problems in their endemic regions. NW arenavirus infection induces a variety of host innate immune responses, which could contribute to the viral pathogenesis and/or influence the final outcome of virus infection in vitro and in vivo. On the other hand, NW arenaviruses have also developed several strategies to counteract the host innate immune response. We will review current knowledge regarding the interplay between the host innate immune response and NW arenavirus infection in vitro and in vivo, with emphasis on viral-encoded proteins and their effect on the type I interferon response.
AB - Arenaviruses are enveloped, negative-stranded RNA viruses that belong to the family Arenaviridae. This diverse family can be further classified into OW (Old World) and NW (New World) arenaviruses based on their antigenicity, phylogeny, and geographical distribution. Many of the NW arenaviruses are highly pathogenic viruses that cause systemic human infections characterized by hemorrhagic fever and/or neurological manifestations, constituting public health problems in their endemic regions. NW arenavirus infection induces a variety of host innate immune responses, which could contribute to the viral pathogenesis and/or influence the final outcome of virus infection in vitro and in vivo. On the other hand, NW arenaviruses have also developed several strategies to counteract the host innate immune response. We will review current knowledge regarding the interplay between the host innate immune response and NW arenavirus infection in vitro and in vivo, with emphasis on viral-encoded proteins and their effect on the type I interferon response.
KW - arenavirus
KW - cytokine
KW - innate immunity
KW - interferon
KW - interferon antagonist
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U2 - 10.1016/j.jmb.2013.09.028
DO - 10.1016/j.jmb.2013.09.028
M3 - Review article
C2 - 24075870
AN - SCOPUS:84887994837
SN - 0022-2836
VL - 425
SP - 4893
EP - 4903
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 24
ER -