Abstract
For evaluation of the effect of levocabastine pretreatment on allergen‐induced rhinitis symptoms, changes in nasal washings, and nasal responsiveness to histamine, 12 asymptomatic patients with documented allergic rhinitis participated in a single‐blind, placebo‐controlled study. Eight‐day treatment with levocabastine (twice in each nostril, four times a day) caused significant reduction in nasal symptoms and inflammatory cell influx after allergen challenge, as compared with placebo administration. Levocabastine inhibited increased nasal reactivity to histamine induced by allergen provocation, as controlled by rhinitis symptoms and albumin level in nasal washings. These data reveal a high effectiveness of levocabastine in the prevention of allergen‐induced rhinitis symptoms. Moreover, its inhibitory effect on inflammatory cell influx and hyperresponsiveness to histamine suggest that levocabastine is more than a simple H1‐receptor antagonist.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 598-601 |
| Number of pages | 4 |
| Journal | Allergy |
| Volume | 48 |
| Issue number | 8 |
| DOIs | |
| State | Published - Nov 1993 |
| Externally published | Yes |
Keywords
- allergic rhinitis
- eosinophils
- hyperreactivity
- levocabastine
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology