Abstract
The influence of formaldehyde on bile secretion and tissue glutathione concentrations was investigated in male Sprague Dawley rats following a sublethal intraperitoneal administration (72 mg/kg). Within 2-3 h of administration formaldehyde caused a 2-fold increase in secretion of bile and significant decrease in the levels of glutathione in liver (39% of control) followed by kidney (33%), lung (31%) and brain (22%). The results indicate a possible protective role of glutathione in the toxicity of formaldehyde.
Original language | English (US) |
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Pages (from-to) | 233-236 |
Number of pages | 4 |
Journal | Research Communications in Chemical Pathology and Pharmacology |
Volume | 53 |
Issue number | 2 |
State | Published - 1986 |
Externally published | Yes |
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology