Inflammation and diabetic retinal microvascular complications

Wenbo Zhang, Hua Liu, Mohamed Al-Shabrawey, Robert Caldwell, Ruth Caldwell

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations


Diabetic retinopathy (DR) is one of the most common complications of diabetes and is a leading cause of blindness in people of the working age in Western countries. A major pathology of DR is microvascular complications such as non-perfused vessels, microaneurysms, dot/blot hemorrhages, cotton-wool spots, venous beading, vascular loops, vascular leakage and neovascularization. Multiple mechanisms are involved in these alternations. This review will focus on the role of inflammation in diabetic retinal microvascular complications and discuss the potential therapies by targeting inflammation.

Original languageEnglish (US)
Pages (from-to)96-103
Number of pages8
JournalJournal of Cardiovascular Disease Research
Issue number2
StatePublished - 2011
Externally publishedYes


  • Diabetic retinopathy
  • inflammation
  • microvascular complications

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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