TY - JOUR
T1 - Inflammation and diabetic retinal microvascular complications
AU - Zhang, Wenbo
AU - Liu, Hua
AU - Al-Shabrawey, Mohamed
AU - Caldwell, Robert
AU - Caldwell, Ruth
N1 - Funding Information:
This work was generously supported by the American Heart Association 11SDG4960005 and the Juvenile Diabetes )RXQGDWLRQ -'5) WR : =KDQJ E\ 1,+ *UDQWV (< DQG 9$ 0HULW $ZDUG WR 5 % &DOGZHOO E\ 1,+ *UDQW +/ WR 5 : &DOGZHOO E\ 1,+ *UDQW (< (to R.B. Caldwell and R.W. Caldwell) and by the American Heart Association SDG00104 and Vision Discovery Institute (GHSU) (to M. Al-Shabrawey).
PY - 2011
Y1 - 2011
N2 - Diabetic retinopathy (DR) is one of the most common complications of diabetes and is a leading cause of blindness in people of the working age in Western countries. A major pathology of DR is microvascular complications such as non-perfused vessels, microaneurysms, dot/blot hemorrhages, cotton-wool spots, venous beading, vascular loops, vascular leakage and neovascularization. Multiple mechanisms are involved in these alternations. This review will focus on the role of inflammation in diabetic retinal microvascular complications and discuss the potential therapies by targeting inflammation.
AB - Diabetic retinopathy (DR) is one of the most common complications of diabetes and is a leading cause of blindness in people of the working age in Western countries. A major pathology of DR is microvascular complications such as non-perfused vessels, microaneurysms, dot/blot hemorrhages, cotton-wool spots, venous beading, vascular loops, vascular leakage and neovascularization. Multiple mechanisms are involved in these alternations. This review will focus on the role of inflammation in diabetic retinal microvascular complications and discuss the potential therapies by targeting inflammation.
KW - Diabetic retinopathy
KW - inflammation
KW - microvascular complications
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U2 - 10.4103/0975-3583.83035
DO - 10.4103/0975-3583.83035
M3 - Review article
C2 - 21814413
AN - SCOPUS:79960789572
SN - 0975-3583
VL - 2
SP - 96
EP - 103
JO - Journal of Cardiovascular Disease Research
JF - Journal of Cardiovascular Disease Research
IS - 2
ER -