Increased Survival in Low Birth Weight Neonates Given Prophylactic Surfactant

David R. Brown, Barry T. Bloom, Morris Cohen, Michael M. Myers, Edmund A. Egan, John Kattwinkel, Paula Delmore, Robert T. Hall, Michael H. Malloy, Ian R. Holzman, Waldemar A. Carlo, Arun K. Pramanik, Mary Anne McCaffree, Kathleen B. Weatherstone, Lynne D. Willett, William H. Topper

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


OBJECTIVE: To compare the effectiveness of a prophylactic surfactant treatment strategy (PRO) to the effectiveness of a rescue (RESC) surfactant treatment strategy in patients at high risk for developing hyaline membrane disease (HMD). STUDY DESIGN: We analyzed data from a retrospective cohort consisting of all patients admitted to the neonatal intensive care units at the centers participating in the recently completed Infasurf-Survanta Comparative Trial. To be in the cohort, a patient had to be admitted during the trial, be <48 hours of age on admission, have a gestational age of <30 weeks, have a birth weight of 501 to 1250 gm, and be free of congenital anomalies. Twelve centers participated in this study. They contributed 1097 patients of whom 381 were treated with a PRO strategy. RESULTS: Survival was significantly higher in the PRO-strategy patients (84% vs 72%, p < 0.05) as was survival without oxygen requirement at a postconceptional age of 36 weeks (60% vs 46%, p < 0.05). In addition, the patients with PRO had a lower prevalence of grade III and IV intraventricular hemorrhage (IVH, 9% vs 14%, p < 0.05). All analyses were controlled for birth weight and type of study center. CONCLUSION: These data support the conclusion that using a PRO treatment strategy results in improved survival in patients at risk for developing HMD. A PRO treatment strategy may also decrease the likelihood of developing a severe IVH.

Original languageEnglish (US)
Pages (from-to)431-435
Number of pages5
JournalJournal of Perinatology
Issue number6 SUPPL. 1
StatePublished - Nov 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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