TY - JOUR
T1 - Increased sensitivity to prostaglandin E2 in old people
AU - Goodwin, J. S.
PY - 1979/12
Y1 - 1979/12
N2 - Prostaglandin E2 acts as a feedback inhibitor on the actions of many hormones and other stimuli. For example, mitogens will cause leukocytes to produce prostaglandin E2, and the prostaglandin E2 inhibits the proliferative response of the leukocytes to the mitogen. We have shown that lymphocytes from healthy subjects over age 70 are much more sensitive to inhibition by prostaglandin E2 than are lymphocytes from younger individuals. In this paper, I hypothesize that there is a generalized increase in sensitivity in all tissues in aging humans, and that this increased sensitivity accounts for many of the physiologic changes of aging.
AB - Prostaglandin E2 acts as a feedback inhibitor on the actions of many hormones and other stimuli. For example, mitogens will cause leukocytes to produce prostaglandin E2, and the prostaglandin E2 inhibits the proliferative response of the leukocytes to the mitogen. We have shown that lymphocytes from healthy subjects over age 70 are much more sensitive to inhibition by prostaglandin E2 than are lymphocytes from younger individuals. In this paper, I hypothesize that there is a generalized increase in sensitivity in all tissues in aging humans, and that this increased sensitivity accounts for many of the physiologic changes of aging.
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U2 - 10.1016/0161-4630(79)90032-6
DO - 10.1016/0161-4630(79)90032-6
M3 - Article
C2 - 550163
AN - SCOPUS:0018640903
SN - 0161-4630
VL - 3
SP - 395
EP - 400
JO - Prostaglandines and Medicine
JF - Prostaglandines and Medicine
IS - 6
ER -