@article{40b565f02dc34118bc12850f82112a54,
title = "Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes",
abstract = "It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which weredeficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.",
author = "Schmalstieg, {Frank C.} and Nelson, {J. Arly} and Mills, {Gordon C.} and Monahan, {Thomas M.} and Goldman, {Armond S.} and Goldblum, {Randall M.}",
note = "Funding Information: From the Departments of Pediatrics and Human Biological Chemistry and Genetics, The University of Texas Medical Branch, and Kettering-Meyer Laboratory, Southern Research Institute. Supported in part by National Institutes of Health Grant No. DHEW RR-00073-14, General Clinical Research Centers Branch, Division of Research Facilities and Resoumes, and National Institutes of Health Grant No. RO1-CA-17057. Dr. Sehmalstieg is the recipient of The Jeanne B. Kempner Scholarship Award, The University of Texas Medical Branch, Galveston, Texas. *Reprint address; Division of Immunology and Allergy, Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77550.",
year = "1977",
month = jul,
doi = "10.1016/S0022-3476(77)80442-3",
language = "English (US)",
volume = "91",
pages = "48--51",
journal = "The Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "1",
}