Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury

K. Yang; J. R. Perez-Polo; X. S. Mu; H. Q. Yan; J. J. Xue; Y. Iwamoto; S. J. Liu; C. E. Dixon; R. L. Hayes

doi:10.1002/(SICI)1097-4547(19960415)44:2<157::AID-JNR8>3.0.CO;2-C

Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury

K. Yang, J. R. Perez-Polo, X. S. Mu, H. Q. Yan, J. J. Xue, Y. Iwamoto, S. J. Liu, C. E. Dixon, R. L. Hayes

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) mRNA expression were measured in a rodent model of traumatic brain injury (TBI) following unilateral injury to the cerebral cortex. To obtain reliable data on the co-expression of neurotrophin genes, adjacent coronal sections from the same rat brains were hybridized in situ with BDNF and NT3 cRNA probes. BDNF mRNA increased at 1, 3, and 5 hr after unilateral cortical injury in the cortex ipsilateral to the injury site and bilaterally in the dorsal hippocampus. NT3 mRNA did not change significantly following injury. Our results suggest that TBI produces rapid increases in BDNF mRNA expression in rat brain without changes in NT3 mRNA expression, a finding which differs from studies of ischemia and seizures. It is possible that increased levels of BDNF mRNA rather than NT3 are important components of pathophysiological responses to TBI.

Original language	English (US)
Pages (from-to)	157-164
Number of pages	8
Journal	Journal of Neuroscience Research
Volume	44
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1097-4547(19960415)44:2<157::AID-JNR8>3.0.CO;2-C
State	Published - 1996

Keywords

BDNF
NT3
gene expression
neurotrophin
traumatic brain injury

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.1002/(SICI)1097-4547(19960415)44:2<157::AID-JNR8>3.0.CO;2-C

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Yang, K., Perez-Polo, J. R., Mu, X. S., Yan, H. Q., Xue, J. J., Iwamoto, Y., Liu, S. J., Dixon, C. E., & Hayes, R. L. (1996). Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury. Journal of Neuroscience Research, 44(2), 157-164. https://doi.org/10.1002/(SICI)1097-4547(19960415)44:2<157::AID-JNR8>3.0.CO;2-C

Yang, K, Perez-Polo, JR, Mu, XS, Yan, HQ, Xue, JJ, Iwamoto, Y, Liu, SJ, Dixon, CE & Hayes, RL 1996, 'Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury', Journal of Neuroscience Research, vol. 44, no. 2, pp. 157-164. https://doi.org/10.1002/(SICI)1097-4547(19960415)44:2<157::AID-JNR8>3.0.CO;2-C

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abstract = "Levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) mRNA expression were measured in a rodent model of traumatic brain injury (TBI) following unilateral injury to the cerebral cortex. To obtain reliable data on the co-expression of neurotrophin genes, adjacent coronal sections from the same rat brains were hybridized in situ with BDNF and NT3 cRNA probes. BDNF mRNA increased at 1, 3, and 5 hr after unilateral cortical injury in the cortex ipsilateral to the injury site and bilaterally in the dorsal hippocampus. NT3 mRNA did not change significantly following injury. Our results suggest that TBI produces rapid increases in BDNF mRNA expression in rat brain without changes in NT3 mRNA expression, a finding which differs from studies of ischemia and seizures. It is possible that increased levels of BDNF mRNA rather than NT3 are important components of pathophysiological responses to TBI.",

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AU - Yang, K.

AU - Perez-Polo, J. R.

AU - Mu, X. S.

AU - Yan, H. Q.

AU - Xue, J. J.

AU - Iwamoto, Y.

AU - Liu, S. J.

AU - Dixon, C. E.

AU - Hayes, R. L.

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N2 - Levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) mRNA expression were measured in a rodent model of traumatic brain injury (TBI) following unilateral injury to the cerebral cortex. To obtain reliable data on the co-expression of neurotrophin genes, adjacent coronal sections from the same rat brains were hybridized in situ with BDNF and NT3 cRNA probes. BDNF mRNA increased at 1, 3, and 5 hr after unilateral cortical injury in the cortex ipsilateral to the injury site and bilaterally in the dorsal hippocampus. NT3 mRNA did not change significantly following injury. Our results suggest that TBI produces rapid increases in BDNF mRNA expression in rat brain without changes in NT3 mRNA expression, a finding which differs from studies of ischemia and seizures. It is possible that increased levels of BDNF mRNA rather than NT3 are important components of pathophysiological responses to TBI.

AB - Levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) mRNA expression were measured in a rodent model of traumatic brain injury (TBI) following unilateral injury to the cerebral cortex. To obtain reliable data on the co-expression of neurotrophin genes, adjacent coronal sections from the same rat brains were hybridized in situ with BDNF and NT3 cRNA probes. BDNF mRNA increased at 1, 3, and 5 hr after unilateral cortical injury in the cortex ipsilateral to the injury site and bilaterally in the dorsal hippocampus. NT3 mRNA did not change significantly following injury. Our results suggest that TBI produces rapid increases in BDNF mRNA expression in rat brain without changes in NT3 mRNA expression, a finding which differs from studies of ischemia and seizures. It is possible that increased levels of BDNF mRNA rather than NT3 are important components of pathophysiological responses to TBI.

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KW - NT3

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Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury

Abstract

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