Incidence and Outcomes of Acute Coronary Syndrome After Transcatheter Aortic Valve Replacement

Amgad Mentias, Milind Y. Desai, Marwan Saad, Phillip A. Horwitz, James D. Rossen, Sidakpal Panaich, Ayman Elbadawi, J. Dawn Abbott, Paul Sorajja, Hani Jneid, E. Murat Tuzcu, Samir Kapadia, Mary Vaughan-Sarrazin

Research output: Contribution to journalArticlepeer-review


Objectives: This study sought to address a knowledge gap by examining the incidence, timing, and predictors of acute coronary syndrome (ACS) after transcatheter aortic valve replacement (TAVR) in Medicare beneficiaries. Background: Evidence about incidence and outcomes of ACS after TAVR is scarce. Methods: We identified Medicare patients who underwent TAVR from 2012 to 2017 and were admitted with ACS during follow-up. We compared outcomes based on the type of ACS: ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), and unstable angina. In patients with non–ST-segment elevation ACS, we compared outcomes based on the treatment strategy (invasive vs. conservative) using inverse probability weighting analysis. Results: Out of 142,845 patients with TAVR, 6,741 patients (4.7%) were admitted with ACS after a median time of 297 days (interquartile range: 85 to 662 days), with 48% of admissions occurring within 6 months. The most common presentation was NSTEMI. Predictors of ACS were history of coronary artery disease, prior revascularization, diabetes, valve-in-TAVR, and acute kidney injury. STEMI was associated with higher 30-day and 1-year mortality compared with NSTEMI (31.4% vs. 15.5% and 51.2% vs. 41.3%, respectively; p < 0.01). Overall, 30.3% of patients with non–ST-segment elevation ACS were treated with invasive approach. On inverse probability weighting analysis, invasive approach was associated with lower adjusted long-term mortality (adjusted hazard ratio: 0.69; 95% confidence interval: 0.66 to 0.73; p < 0.01) and higher risk of repeat revascularization (adjusted hazard ratio: 1.29; 95% confidence interval: 1.16 to 1.43; p < 0.001). Conclusions: After TAVR, ACS is infrequent (<5%), and the most common presentation is NSTEMI. Occurrence of STEMI after TAVR is associated with a high mortality with nearly one-third of patients dying within 30 days. Optimization of care is needed for post-TAVR ACS patients and if feasible, invasive approach should be considered in these high-risk patients.

Original languageEnglish (US)
Pages (from-to)938-950
Number of pages13
JournalJACC: Cardiovascular Interventions
Issue number8
StatePublished - Apr 27 2020
Externally publishedYes


  • acute coronary syndrome
  • percutaneous coronary intervention
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Incidence and Outcomes of Acute Coronary Syndrome After Transcatheter Aortic Valve Replacement'. Together they form a unique fingerprint.

Cite this