In vivo ANTI‐NGF induces sprouting of sensory axons in dorsal roots

C. E. Hulsebosch, J. R. Perez‐Polo, R. E. Coggeshall

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Newborn rats were given subcutaneous injections of antibodies to mouse β ‐NGF (ANTI‐NGF) daily for 1 month. The number of neurons in T4‐T6 dorsal root ganglia (DRG) and the numbers of myelinated and unmyelinated axons in the dorsal roots of the same segments were counted in the ANTI‐NGF animals and in normal littermates. The ANTI‐NGF rats had 38% fewer neurons in thoracic ganglia but 17% more myelinated and 40% more unmyelinated fibers than their untreated littermates. Dorsal root ganglion cells also have a larger average size in the ANTI‐NGF animals, which we interpret as a disproportionate loss of small cells. These data are interpreted as showing that some dorsal root ganglion cells, principally small ones, die when endogenous NGF is inactivated, and that the remaining cells emit more processes than normal. Thus, removal of NGF has what appears to be a paradoxical effect, a reduction in dorsal root ganglion cell numbers but an increase in dorsal root axon numbers. The relation of myelin thickness to fiber diameter is also altered, with small fibers being more thinly myelinated in the ANTI‐NGF group. Thus, Schwann cell‐neuronal interactions are also affected by inactivation of NGF.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalJournal of Comparative Neurology
Issue number3
StatePublished - May 15 1987


  • antibodies to nerve growth factor
  • axonal sprouting
  • nerve growth factor
  • unmyelinated axons

ASJC Scopus subject areas

  • General Neuroscience


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