In vitro myometrial contractility profiles of different pharmacological agents used for induction of labor

Giuseppe Chioss, Maged M. Costantine, Egle Bytautiene, Ancizar Betancourt, Gary D.V. Hankins, George R. Saade, Monica Longo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


ObjectiveTo investigate the effects of different pharmacological induction agents on myometrial contractility. Study DesignMyometrial biopsies were obtained from 13 term nonlaboring women undergoing scheduled cesarean delivery. Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (1010 mol/L to 105 mol/L) of prostaglandin E1 (PGE1), E2 (PGE2), and oxytocin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using one-way analysis of variance on ranks with Dunn post hoc test. ResultsOxytocin-induced myometrial contractility was superior to PGE1, PGE2, and time controls (CTR) at all the concentrations tested. When only prostaglandins were compared with CTR, PGE1 105 mol/L increased myometrial contractility, and PGE2 had no effects. ConclusionOxytocin and prostaglandins have different effects on myometrial contractility accounting for different mechanisms of action and side effects. The increased uterine contractility observed with PGE1 as compared with PGE2 can contribute to explain the higher success of vaginal delivery.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalAmerican Journal of Perinatology
Issue number9
StatePublished - 2012
Externally publishedYes


  • organ chamber
  • oxytocin
  • prostaglandin E1
  • prostaglandin E2
  • uterine contractility

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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