Implications for Therapy

Ivona Pandrea, Alan L. Landay

Research output: Chapter in Book/Report/Conference proceedingChapter


Simian immunodeficiency viruses (SIVs) are a large group of lentiviruses that naturally infect more than 40 African nonhuman primate (NHP) species. SIV prevalence in the wild ranges from 2% to more than 80% in different species. The simian lentiviruses form one of the five serogroups of the Lentiviridae genus, consisting of three species: human immunodeficiency virus 1 (HIV-1), human immunodeficiency virus 2 (HIV-2), and SIV. The SIVs from naturally infected NHPs of African origin hosts are designated by a three-letter abbreviation of the host primate species. In addition, the number of SIVs naturally infecting different African NHP species is high. There are major intrinsic limitations to the development of animal models in different species of African NHP hosts: numerous SIVs are only known from sequences, therefore they cannot be used in pathogenesis/treatment studies; numerous African NHPs that are natural hosts of SIVs are extremely endangered which generally precludes invasive studies in these hosts; and there are no currently available colonies for most of the African NHPs.

Original languageEnglish (US)
Title of host publicationModels of Protection Against HIV/SIV
PublisherElsevier Inc.
Number of pages52
ISBN (Print)9780123877154
StatePublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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