TY - GEN
T1 - Implantation of rat islet-filled micromachined biocapsules in mice
AU - Desai, Tejal A.
AU - Hansford, Derek J.
AU - Ferrari, Mauro
AU - Rastellini, Cristiana
PY - 1999
Y1 - 1999
N2 - This study investigates whether microfabricated silicon-based biocapsules, with uniform membrane pore sizes in the tens of nanometer range, can provide immunoprotection of rat islets transplanted into a mouse model. By utilizing microfabrication technology, biocapsules are fabricated with membranes having precisely controlled and uniform pore sizes, allowing one to optimize parameters specifically for the immunoisolation of hormone-secreting cells. The study evaluates biocompatibility and short term therapeutic efficacy for implanted biocapsules.
AB - This study investigates whether microfabricated silicon-based biocapsules, with uniform membrane pore sizes in the tens of nanometer range, can provide immunoprotection of rat islets transplanted into a mouse model. By utilizing microfabrication technology, biocapsules are fabricated with membranes having precisely controlled and uniform pore sizes, allowing one to optimize parameters specifically for the immunoisolation of hormone-secreting cells. The study evaluates biocompatibility and short term therapeutic efficacy for implanted biocapsules.
UR - http://www.scopus.com/inward/record.url?scp=0033341155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033341155&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0033341155
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 749
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -