Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy

Ke Zhu, Jianxun Yi, Yajuan Xiao, Yumei Lai, Pingping Song, Wei Zheng, Hongli Jiao, Jie Fan, Chuanyue Wu, Di Chen, Jingsong Zhou, Guozhi Xiao

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The effects of ALS on bone homeostasis are poorly understood. Results: ALS mice with muscle atrophy have reduced bone mass associated with multiple impairments of osteoblast properties and striking acceleration of osteoclast formation in bone. Conclusion: Abnormal bone remodeling results in dramatic bone loss during the progression of muscle atrophy in ALS mice. Significance: This study may help to define therapeutic targets for ALS patients.

Original languageEnglish (US)
Pages (from-to)8081-8094
Number of pages14
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
StatePublished - Mar 27 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy'. Together they form a unique fingerprint.

Cite this