Abstract
Background: The effects of ALS on bone homeostasis are poorly understood. Results: ALS mice with muscle atrophy have reduced bone mass associated with multiple impairments of osteoblast properties and striking acceleration of osteoclast formation in bone. Conclusion: Abnormal bone remodeling results in dramatic bone loss during the progression of muscle atrophy in ALS mice. Significance: This study may help to define therapeutic targets for ALS patients.
Original language | English (US) |
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Pages (from-to) | 8081-8094 |
Number of pages | 14 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 13 |
DOIs | |
State | Published - Mar 27 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology