Impact of pre-burn statin use on metabolic and cardiovascular disorders

Tsola A. Efejuku, Grace Obanigba, Dominique Johnson, Ann Obi, Taylor Hallman, Juquan Song, Amina El Ayadi, Mukaila Raji, Steven E. Wolf

Research output: Contribution to journalArticlepeer-review


Introduction: Statins are among the most widely prescribed medications with proven effectiveness in patients with hyperlipidemia and atherosclerotic cardiovascular diseases. We investigated the relationship between statin use, metabolic and cardiovascular outcomes after burn. Methods: We utilized data from the TriNetX electronic health database. Burn patients with prior statin use were compared to patients without prior use and analyzed the occurrence of metabolic and cardiovascular disorders. Results: Prior statin use burn patients were 1.33 times as likely to develop hyperglycemia, 1.20 times for cardiac arrhythmia, 1.70 times for coronary artery disease (CAD), 1.10 times for sepsis, and 0.80 times for death. High percent TBSA burn, male sex, and lipophilic statin use were associated with higher odds of outcome development. Conclusion: Prior statin use in severely burned patients is associated with an increased risk of developing hyperglycemia, arrhythmias, and CAD, with higher odds in males, higher TBSA burn, and lipophilic statin users.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalAmerican Journal of Surgery
Issue number4
StatePublished - Oct 2023


  • Burn
  • Cardiovascular outcomes
  • Metabolic disorders
  • Outcomes
  • Patients database
  • Statin

ASJC Scopus subject areas

  • Surgery


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