Immunophenotypic alterations in acute and early HIV infection

Lena Al-Harthi, Sam MaWhinney, Elizabeth Connick, Robert T. Schooley, Jeri E. Forster, Constance Benson, Melanie Thompson, Franklyn Judson, Frank Palella, Alan Landay

Research output: Contribution to journalArticlepeer-review


To understand the extent of immune dysregulation in primary HIV infection (PHI) and the impact of antiretroviral therapy (ART) on restoring these abnormalities, we longitudinally evaluated 52 subjects (Acute-Treated (AT); Early-Treated (ET); Early Untreated (EU)) for markers of activation, proliferation, and function on T cells. ET and AT patients differed by 0.54 log viral load (VL) at baseline but did not differ thereafter by more than 0.34 log10 VL. AT subjects had higher CD8+ T cell counts and expression of markers indicative of CD8+ T cell activation (CD38), and proliferation (Ki67), at baseline, than ET subjects but were not different 48 weeks post-ART. Although acute PHI is marked by higher level of immune activation than early PHI, virologic and immunologic responses were similar post-ART, suggesting that the extent of immunologic recovery is not negatively impacted by a delay of treatment beyond the acute stage of disease.

Original languageEnglish (US)
Pages (from-to)299-308
Number of pages10
JournalClinical Immunology
Issue number3
StatePublished - Dec 2007
Externally publishedYes


  • Acute HIV
  • Early HIV
  • Immune reconstitution
  • Immunophenotyping
  • Primary HIV infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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