Immunohistochemical study of the phrenic ganglion

R. Shane Tubbs, William Stetler, David R. Kelly, Danitra Blevins, Robert Lott, Rita Humphrey, Mohammadali M. Shoja, Marios Loukas

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Peripheral nerve 'pseudoganglia' are described in the literature with little focus on histology. The phrenic ganglia, which are located on the inferior surface of the diaphragm and are associated with the phrenic nerves, have been described by some authors as potentially sympathetic ganglia although this, to the authors'knowledge, has not been proven. The purpose of the present study was to elucidate further the true autonomic nature of this collection of nerve cell bodies. In eight fresh adult cadavers <6 h after death, the left and right phrenic ganglia were harvested and subjected to immunochemistry. All phrenic ganglia were vasoactive intestinal polypeptide negative but tyrosine hydroxylase positive. These findings indicate that the phrenic ganglia are sympathetic ganglia with most likely a vasomotor function.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalAnatomical Science International
Issue number3
StatePublished - Sep 2008
Externally publishedYes


  • Anatomy
  • Diaphragm
  • Pseudoganglion

ASJC Scopus subject areas

  • Anatomy


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