@article{33584bb61c864e2d8716bbb821718c45,
title = "Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial",
abstract = "In a randomized clinical trial, we compare early neutralizing antibody responses after boosting with bivalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines based on either BA.1 or BA.4/BA.5 Omicron spike protein combined with wild-Type spike. Responses against SARS-CoV-2 variants exhibited the greatest reduction in titers against currently circulating Omicron subvariants for both bivalent vaccines.",
keywords = "SARS-CoV-2, vaccine, variant",
author = "Branche, {Angela R.} and Rouphael, {Nadine G.} and Cecilia Losada and Baden, {Lindsey R.} and Anderson, {Evan J.} and Luetkemeyer, {Anne F.} and Diemert, {David J.} and Winokur, {Patricia L.} and Presti, {Rachel M.} and Kottkamp, {Angelica C.} and Falsey, {Ann R.} and Frey, {Sharon E.} and Richard Rupp and Mart{\'i}n B{\"a}cker and Novak, {Richard M.} and Walter, {Emmanuel B.} and Jackson, {Lisa A.} and Little, {Susan J.} and Immergluck, {Lilly C.} and Mahgoub, {Siham M.} and Whitaker, {Jennifer A.} and Babu, {Tara M.} and Goepfert, {Paul A.} and Fusco, {Dahlene N.} and Atmar, {Robert L.} and Posavad, {Christine M.} and Antonia Netzl and Smith, {Derek J.} and Kalyani Telu and Jinjian Mu and Mat Makowski and Makhene, {Mamodikoe K.} and Sonja Crandon and Montefiori, {David C.} and Roberts, {Paul C.} and Beigel, {John H.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s).",
year = "2023",
month = aug,
day = "15",
doi = "10.1093/cid/ciad209",
language = "English (US)",
volume = "77",
pages = "560--564",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "4",
}