@article{ee412b3479434c2796f5a3ffc0da52e2,
title = "Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants",
abstract = "As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, and short-term durability of binding and pseudovirus-neutralizing antibody (PsVNA) responses following a single booster dose of NVX-CoV2373 in adults primed with either Ad26.COV2.S, mRNA-1273, or BNT162b2 vaccines. NVX-CoV2373 as a heterologous booster was immunogenic and associated with no safety concerns through Day 91. Fold-rises in PsVNA titers from baseline (Day 1) to Day 29 were highest for prototypic D614G variant and lowest for more recent Omicron sub-lineages BQ.1.1 and XBB.1. Peak humoral responses against all SARS-CoV-2 variants were lower in those primed with Ad26.COV2.S than with mRNA vaccines. Prior SARS CoV-2 infection was associated with substantially higher baseline PsVNA titers, which remained elevated relative to previously uninfected participants through Day 91. These data support the use of heterologous protein-based booster vaccines as an acceptable alternative to mRNA or adenoviral-based COVID-19 booster vaccines. This trial was conducted under ClinicalTrials.gov: NCT04889209.",
author = "{the DMID 21-0012 Study Group} and Lyke, {Kirsten E.} and Atmar, {Robert L.} and {Dominguez Islas}, Clara and Posavad, {Christine M.} and Deming, {Meagan E.} and Branche, {Angela R.} and Christine Johnston and {El Sahly}, {Hana M.} and Srilatha Edupuganti and Mulligan, {Mark J.} and Jackson, {Lisa A.} and Rupp, {Richard E.} and Rostad, {Christina A.} and Coler, {Rhea N.} and Mart{\'i}n B{\"a}cker and Kottkamp, {Angelica C.} and Babu, {Tara M.} and David Dobrzynski and Martin, {Judith M.} and Brady, {Rebecca C.} and Frenck, {Robert W.} and Kumaravel Rajakumar and Karen Kotloff and Nadine Rouphael and Daniel Szydlo and Rahul PaulChoudhury and Archer, {Janet I.} and Sonja Crandon and Brian Ingersoll and Amanda Eaton and Brown, {Elizabeth R.} and McElrath, {M. Juliana} and Neuzil, {Kathleen M.} and Stephens, {David S.} and Post, {Diane J.} and Lin, {Bob C.} and Leonid Serebryannyy and Beigel, {John H.} and Montefiori, {David C.} and Roberts, {Paul C.} and Anderson, {Evan J.} and Megan Berman and Cohen, {Kristen W.} and {De Rosa}, Stephen and Michelle Dickey and Dong, {Jennifer Lee} and Madison Ellis and Falsey, {Ann R.} and Fleming, {Andrew B.} and Laura Porterfield",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1038/s41541-023-00693-z",
language = "English (US)",
volume = "8",
journal = "npj Vaccines",
issn = "2059-0105",
publisher = "Nature Publishing Group",
number = "1",
}