Immune modulation of HIV replication: Relevance to HIV immuno- and neuro-pathogenesis

Elizabeth Z. Managlia, Deborah Carroll, Andrew Zloza, Lena Al-Harthi

Research output: Contribution to journalReview articlepeer-review


Much attention has been focused on CD4+ memory/primed T cells and monocytes/macrophages as the predominant targets of HIV infection. Considerable evidence, however, indicates that cell types that are classically not permissive to HIV infection, can be a potent source of productive virus replication in response to immune modulation. This immune modulation can be in the form of cytokine stimulation pre- or post-infection or by activating these "non-conventional" targets. In this review, we will provide evidence for immune modulation of HIV infection with special emphasis on immune modulation of HIV replication in classically non-HIV permissive primary cells of both lymphoid and non-lymphoid origins. We will also examine the impact of HIV infection of these non-conventional targets as they pertain to both HIV immuno- and neuro-pathogenesis.

Original languageEnglish (US)
Pages (from-to)395-401
Number of pages7
JournalCurrent HIV Research
Issue number4
StatePublished - Oct 2004
Externally publishedYes


  • Cytokine therapy
  • HIV
  • Immune reconstitution
  • Neuropathogenesis

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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