Immune-mediated cognition impairment in multiple sclerosis

Zahra Kolahchi, Sareh Saien, Alireza Soltani Khaboushan, Erfan Naghavi, George Perry, Nima Rezaei

Research output: Chapter in Book/Report/Conference proceedingChapter


Multiple sclerosis (MS) is a chronic disorder associated with inflammation and degeneration of neurons in the central nervous system (CNS). Cognitive impairment is one of the most common MS symptoms that can be recognized in 40%–70% of MS patients. In this chapter, we have summarized the literature about the role of immune factors in cognitive impairment. Cognitive impairment in MS patients is influenced by immune cells and cytokines, such as IL-6, IL-8, IL-10, IL-17, IL-18, and TNF-α, which may reveal the underlying mechanisms that are therapeutically addressable.

Original languageEnglish (US)
Title of host publicationTranslational Neuroimmunology
Subtitle of host publicationMultiple Sclerosis: Volume 8
Number of pages24
ISBN (Electronic)9780443185786
ISBN (Print)9780443185793
StatePublished - Jan 1 2023
Externally publishedYes


  • B cells
  • Cognitive impairment
  • Cytokines
  • Multiple sclerosis
  • Neuroinflammation
  • T cells

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


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