Immune-mediated cognition impairment in multiple sclerosis

Zahra Kolahchi; Sareh Saien; Alireza Soltani Khaboushan; Erfan Naghavi; George Perry; Nima Rezaei

doi:10.1016/B978-0-443-18578-6.00012-X

Immune-mediated cognition impairment in multiple sclerosis

Zahra Kolahchi, Sareh Saien, Alireza Soltani Khaboushan, Erfan Naghavi, George Perry, Nima Rezaei

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Multiple sclerosis (MS) is a chronic disorder associated with inflammation and degeneration of neurons in the central nervous system (CNS). Cognitive impairment is one of the most common MS symptoms that can be recognized in 40%–70% of MS patients. In this chapter, we have summarized the literature about the role of immune factors in cognitive impairment. Cognitive impairment in MS patients is influenced by immune cells and cytokines, such as IL-6, IL-8, IL-10, IL-17, IL-18, and TNF-α, which may reveal the underlying mechanisms that are therapeutically addressable.

Original language	English (US)
Title of host publication	Translational Neuroimmunology
Subtitle of host publication	Multiple Sclerosis: Volume 8
Publisher	Elsevier
Pages	209-232
Number of pages	24
ISBN (Electronic)	9780443185786
ISBN (Print)	9780443185793
DOIs	https://doi.org/10.1016/B978-0-443-18578-6.00012-X
State	Published - Jan 1 2023
Externally published	Yes

Keywords

B cells
Cognitive impairment
Cytokines
Multiple sclerosis
Neuroinflammation
T cells

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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10.1016/B978-0-443-18578-6.00012-X

Cite this

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abstract = "Multiple sclerosis (MS) is a chronic disorder associated with inflammation and degeneration of neurons in the central nervous system (CNS). Cognitive impairment is one of the most common MS symptoms that can be recognized in 40%–70% of MS patients. In this chapter, we have summarized the literature about the role of immune factors in cognitive impairment. Cognitive impairment in MS patients is influenced by immune cells and cytokines, such as IL-6, IL-8, IL-10, IL-17, IL-18, and TNF-α, which may reveal the underlying mechanisms that are therapeutically addressable.",

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AU - Kolahchi, Zahra

AU - Saien, Sareh

AU - Khaboushan, Alireza Soltani

AU - Naghavi, Erfan

AU - Perry, George

AU - Rezaei, Nima

PY - 2023/1/1

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N2 - Multiple sclerosis (MS) is a chronic disorder associated with inflammation and degeneration of neurons in the central nervous system (CNS). Cognitive impairment is one of the most common MS symptoms that can be recognized in 40%–70% of MS patients. In this chapter, we have summarized the literature about the role of immune factors in cognitive impairment. Cognitive impairment in MS patients is influenced by immune cells and cytokines, such as IL-6, IL-8, IL-10, IL-17, IL-18, and TNF-α, which may reveal the underlying mechanisms that are therapeutically addressable.

AB - Multiple sclerosis (MS) is a chronic disorder associated with inflammation and degeneration of neurons in the central nervous system (CNS). Cognitive impairment is one of the most common MS symptoms that can be recognized in 40%–70% of MS patients. In this chapter, we have summarized the literature about the role of immune factors in cognitive impairment. Cognitive impairment in MS patients is influenced by immune cells and cytokines, such as IL-6, IL-8, IL-10, IL-17, IL-18, and TNF-α, which may reveal the underlying mechanisms that are therapeutically addressable.

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KW - Cognitive impairment

KW - Cytokines

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KW - Neuroinflammation

KW - T cells

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Immune-mediated cognition impairment in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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