Imaging biochemical recurrence after prostatectomy: Where are we headed?

Peeyush Bhargava, Gregory Ravizzini, Brian F. Chapin, Vikas Kundra

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


OBJECTIVE: In this article, we discuss the evolving roles of imaging modalities in patients presenting with biochemical recurrence after prostatectomy. CONCLUSION: Multiple imaging modalities are currently available to evaluate patients with prostate cancer presenting with biochemical recurrence after prostatectomy. Multiparametric MRI (mpMRI) focuses on the postsurgical bed as well as regional lymph nodes and bones. PET/CT studies using 18F-fluciclovine, 11C-choline, and prostate-specific membrane antigen (PSMA) ligands are useful in detecting locoregional and distant metastasis. Multiparametric MRI is preferred for patients with low risk of metastasis for localizing recurrence in prostate bed as well as pelvic lymph node and bone recurrence. Moreover, mpMRI aids in guiding biopsy and additional salvage treatments. For patients with high risk of metastatic disease, both mpMRI and whole-body PET/CT may be performed. PET/MRI using 68Ga-PSMA has potential to enable a one-stop shop for local recurrence and metastatic disease evaluation, and clinical trials of PET/MRI are ongoing.

Original languageEnglish (US)
Pages (from-to)1248-1258
Number of pages11
JournalAmerican Journal of Roentgenology
Issue number6
StatePublished - Jun 2020
Externally publishedYes


  • Biochemical recurrence
  • Imaging
  • MRI
  • PET/CT
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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