IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: Regulation of T helper 1/T helper 2 responses

György Haskó, Csaba Szabó

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

1. Interleukin-12 (IL-12) is a pivotal cytokine in driving the immune system towards a T helper (Th)1 type response and preventing a Th2 type immune profile. Therefore, IL-12 is indispensable in the defense against certain, mainly intracellular pathogens, but overproduction of this cytokine is crucially involved in the etiology of several inflammatory and autoimmune diseases. 2. Hence, IL-12 is an ideal target for pharmacological intervention in the therapy of autoimmune and inflammatory diseases. 3. The production of IL-12 and a resultant Th1 type immune response can be suppressed with several pharmacological approaches including modulation of intracellular cyclic AMP levels, glucocorticoids and nuclear factor-κB inhibition. IL-12 responsiveness may be inhibited using anti-IL-12 antibodies, soluble IL-12 receptors or the IL-12 p46 homodimer. 4. Exploitation of these approaches may provide novel means for the experimental therapy of a variety of pathophysiological states.

Original languageEnglish (US)
Pages (from-to)1295-1304
Number of pages10
JournalBritish Journal of Pharmacology
Volume127
Issue number6
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Autoimmune disease
  • Catecholamine
  • Cytokines
  • Inflammation
  • Interferon-γ
  • Interleukin-10
  • Interleukin-2
  • Interleukin-4
  • Nitric oxide
  • Transcription factors

ASJC Scopus subject areas

  • Pharmacology

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