IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors

F. Silvestris; J. S. Goodwin; R. C. Williams

doi:10.1007/BF02031890

IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors

F. Silvestris, J. S. Goodwin, R. C. Williams

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

IgM, IgA, and IgG Rheumatoid Factors (RF) were measured by ELISA assay in serum from 26 patients with definite rheumatoid arthritis (RA) and 11 normal controls. IgM-RF was assayed by ELISA, radioimmunoassay,and also by the standard latex fixation test in all sera from RA patients. In patients with RA quantitative amounts of IgM, IgA, and IgG-RF as estimated by ELISA were highly correlated. Significant correlations were found between a physician's rating of disease activity and IgG-RF (r=0.44; p<.02) and IgA-RF (r=0.38; p=.06 but not for IgM-RF as measured in any of the three assays.

Original language	English (US)
Pages (from-to)	392-398
Number of pages	7
Journal	Clinical Rheumatology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1007/BF02031890
State	Published - Dec 1985
Externally published	Yes

Keywords

ELISA
Radioimmunoassay
Rheumatoid Factors

ASJC Scopus subject areas

Rheumatology

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10.1007/BF02031890

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title = "IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors",

abstract = "IgM, IgA, and IgG Rheumatoid Factors (RF) were measured by ELISA assay in serum from 26 patients with definite rheumatoid arthritis (RA) and 11 normal controls. IgM-RF was assayed by ELISA, radioimmunoassay,and also by the standard latex fixation test in all sera from RA patients. In patients with RA quantitative amounts of IgM, IgA, and IgG-RF as estimated by ELISA were highly correlated. Significant correlations were found between a physician's rating of disease activity and IgG-RF (r=0.44; p<.02) and IgA-RF (r=0.38; p=.06 but not for IgM-RF as measured in any of the three assays.",

keywords = "ELISA, Radioimmunoassay, Rheumatoid Factors",

author = "F. Silvestris and Goodwin, {J. S.} and Williams, {R. C.}",

year = "1985",

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doi = "10.1007/BF02031890",

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T1 - IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors

AU - Silvestris, F.

AU - Goodwin, J. S.

AU - Williams, R. C.

PY - 1985/12

Y1 - 1985/12

N2 - IgM, IgA, and IgG Rheumatoid Factors (RF) were measured by ELISA assay in serum from 26 patients with definite rheumatoid arthritis (RA) and 11 normal controls. IgM-RF was assayed by ELISA, radioimmunoassay,and also by the standard latex fixation test in all sera from RA patients. In patients with RA quantitative amounts of IgM, IgA, and IgG-RF as estimated by ELISA were highly correlated. Significant correlations were found between a physician's rating of disease activity and IgG-RF (r=0.44; p<.02) and IgA-RF (r=0.38; p=.06 but not for IgM-RF as measured in any of the three assays.

AB - IgM, IgA, and IgG Rheumatoid Factors (RF) were measured by ELISA assay in serum from 26 patients with definite rheumatoid arthritis (RA) and 11 normal controls. IgM-RF was assayed by ELISA, radioimmunoassay,and also by the standard latex fixation test in all sera from RA patients. In patients with RA quantitative amounts of IgM, IgA, and IgG-RF as estimated by ELISA were highly correlated. Significant correlations were found between a physician's rating of disease activity and IgG-RF (r=0.44; p<.02) and IgA-RF (r=0.38; p=.06 but not for IgM-RF as measured in any of the three assays.

KW - ELISA

KW - Radioimmunoassay

KW - Rheumatoid Factors

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IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors

Abstract

Keywords

ASJC Scopus subject areas

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