IFN-λ: A new inducer of local immunity against cancer and infections

Ahmed Lasfar; Andrew Zloza; Andrew de la Torre; Karine A. Cohen-Solal

doi:10.3389/fimmu.2016.00598

IFN-λ: A new inducer of local immunity against cancer and infections

Ahmed Lasfar, Andrew Zloza, Andrew de la Torre, Karine A. Cohen-Solal

Research output: Contribution to journal › Review article › peer-review

Abstract

IFN-λ is the newly established type III IFN with unique immunomodulatory functions. In contrast to the IFN-α/β family and to some extent IFN-γ, IFN-λ is apparently acting in specific areas of the body to activate resident immune cells and induces a local immunity, instrumental in preventing particular infections and also keeping transformed cells under control. Mucosal areas of lung and gastrointestinal tracts are now under scrutiny to elucidate the immune mechanisms triggered by IFN-λ and leading to viral protection. New evidence also indicates the crucial role of IFN-λ in promoting innate immunity in solid cancer models. Based on its unique biological activities among the IFN system, new immunotherapeutic approaches are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances of IFN-λ immunomodulatory functions. We also discuss the perspectives of IFN-λ as a therapeutic agent.

Original language	English (US)
Article number	598
Journal	Frontiers in immunology
Volume	7
Issue number	DEC
DOIs	https://doi.org/10.3389/fimmu.2016.00598
State	Published - 2016
Externally published	Yes

Keywords

IFN-λ
Immunotherapy of cancer
Inflammation
Mucosal immunity
NK cells
Viral infections

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "IFN-λ: A new inducer of local immunity against cancer and infections",

abstract = "IFN-λ is the newly established type III IFN with unique immunomodulatory functions. In contrast to the IFN-α/β family and to some extent IFN-γ, IFN-λ is apparently acting in specific areas of the body to activate resident immune cells and induces a local immunity, instrumental in preventing particular infections and also keeping transformed cells under control. Mucosal areas of lung and gastrointestinal tracts are now under scrutiny to elucidate the immune mechanisms triggered by IFN-λ and leading to viral protection. New evidence also indicates the crucial role of IFN-λ in promoting innate immunity in solid cancer models. Based on its unique biological activities among the IFN system, new immunotherapeutic approaches are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances of IFN-λ immunomodulatory functions. We also discuss the perspectives of IFN-λ as a therapeutic agent.",

keywords = "IFN-λ, Immunotherapy of cancer, Inflammation, Mucosal immunity, NK cells, Viral infections",

author = "Ahmed Lasfar and Andrew Zloza and {de la Torre}, Andrew and Cohen-Solal, {Karine A.}",

note = "Publisher Copyright: {\textcopyright} 2016 Lasfar, Zloza, de la Torre and Cohen-Solal.",

year = "2016",

doi = "10.3389/fimmu.2016.00598",

language = "English (US)",

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T2 - A new inducer of local immunity against cancer and infections

AU - Lasfar, Ahmed

AU - Zloza, Andrew

AU - de la Torre, Andrew

AU - Cohen-Solal, Karine A.

PY - 2016

Y1 - 2016

N2 - IFN-λ is the newly established type III IFN with unique immunomodulatory functions. In contrast to the IFN-α/β family and to some extent IFN-γ, IFN-λ is apparently acting in specific areas of the body to activate resident immune cells and induces a local immunity, instrumental in preventing particular infections and also keeping transformed cells under control. Mucosal areas of lung and gastrointestinal tracts are now under scrutiny to elucidate the immune mechanisms triggered by IFN-λ and leading to viral protection. New evidence also indicates the crucial role of IFN-λ in promoting innate immunity in solid cancer models. Based on its unique biological activities among the IFN system, new immunotherapeutic approaches are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances of IFN-λ immunomodulatory functions. We also discuss the perspectives of IFN-λ as a therapeutic agent.

AB - IFN-λ is the newly established type III IFN with unique immunomodulatory functions. In contrast to the IFN-α/β family and to some extent IFN-γ, IFN-λ is apparently acting in specific areas of the body to activate resident immune cells and induces a local immunity, instrumental in preventing particular infections and also keeping transformed cells under control. Mucosal areas of lung and gastrointestinal tracts are now under scrutiny to elucidate the immune mechanisms triggered by IFN-λ and leading to viral protection. New evidence also indicates the crucial role of IFN-λ in promoting innate immunity in solid cancer models. Based on its unique biological activities among the IFN system, new immunotherapeutic approaches are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances of IFN-λ immunomodulatory functions. We also discuss the perspectives of IFN-λ as a therapeutic agent.

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KW - Immunotherapy of cancer

KW - Inflammation

KW - Mucosal immunity

KW - NK cells

KW - Viral infections

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IFN-λ: A new inducer of local immunity against cancer and infections

Abstract

Keywords

ASJC Scopus subject areas

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