Identification of human appendicitis by in vitro nuclear magnetic resonance

Danny O. Jacobs, R. G. Settle, John R. Clarke, Scott O. Trerotola, A. K. Sachdeva, Gerald L. Wolf, John L. Rombeau

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The spin-lattice relaxation time, T1 as determined by nuclear magnetic resonance techniques, correlates positively with tissue water content. The latter relationship has been observed in rabbits with experimentally induced appendicitis whose inflamed appendiceal tissues had significantly higher T1's and water contents than tissue from normal controls. The present experiment studied these relationships in humans. Tissue water content and T1 were measured on appendiceal tissue from 10 patients with documented appendicitis and from 6 controls without the disease. All T1's were determined within 30-60 min of removal of the appendix at operation. The mean in vitro T1 of appendiceal tissue from patients with appendicitis was significantly higher than that of controls (527 ± 15 msec versus 430 ± 17 msec, mean ± SEM, P < 0.002). In addition, a strong positive correlation was noted between T1 and tissue water content (r = 0.70, P < 0.01). Based on these findings, the use of in vivo magnetic resonance imaging techniques to detect human appendicitis noninvasively warrants investigation.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalJournal of Surgical Research
Issue number2
StatePublished - Feb 1990
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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