Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs

In a canine model of global cerebral ischemia, 6 dogs received a saline placebo prior to the event and 5 received 12.5 mg/kg ibuprofen. Cerebral venous outflow from the confluence of the sagittal and transverse sinuses, systolic and diastolic arterial pressure, cardiac output, pH, Paco₂, Pao₂, and arterial and sagittal sinus thromboxane B₂ and 6-keto-PGF_1α were measured at intervals up to 120 minutes thereafter. Postischemi ccerebral hypo perfusion was significantly unproved in the ibuprofen pretreatment group. Control dogs showed significant increases in sagittal sinus post ischemic thromboxane B₂ concentrations, but pretreated dogs showed nearly complete inhibition of postischemic thromboxane B₂ production. Pretreated dogs also had significantly lower levels of 6-keto-PGF_1α from the sagittal sinus. There were no significant differences in the other variables at any interval. We conclude that ibuprofen ameliorates postischemic cerebral hypoperfusion, and that this improvement is associated with decreased sagittal sinus levels of thromboxane B₂ and 6-keto-PGF_1α.