Ibuprofen as a template molecule for drug design against Ebola virus

Slobodan Paessler; Cheng Huang; Milan Sencanski; Nevena Veljkovic; Vladimir Perovic; Sanja Glisic; Veljko Veljkovic

doi:10.2741/4627

Ibuprofen as a template molecule for drug design against Ebola virus

Slobodan Paessler, Cheng Huang, Milan Sencanski, Nevena Veljkovic, Vladimir Perovic, Sanja Glisic, Veljko Veljkovic

Pathology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.

Original language	English (US)
Pages (from-to)	947-953
Number of pages	7
Journal	Frontiers in Bioscience - Landmark
Volume	23
Issue number	5
DOIs	https://doi.org/10.2741/4627
State	Published - Jan 1 2018

Keywords

Drug Repositioning
Ebola virus
Entry Inhibitors
Glycoprotein
Ibuprofen

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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AU - Sencanski, Milan

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AU - Perovic, Vladimir

AU - Glisic, Sanja

AU - Veljkovic, Veljko

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KW - Glycoprotein

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Ibuprofen as a template molecule for drug design against Ebola virus

Abstract

Keywords

ASJC Scopus subject areas

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