Hypothesis: intracellular acidification contributes to infertility in varicocele

Kamyar Ghabili, Mohammadali M. Shoja, Paul S. Agutter, Ashok Agarwal

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We suggest that varicocele leads to male factor infertility by a mechanism involving underperfusion of the testis, a shortfall in glucose supply to the tissue, decreased flux through the pentose phosphate pathway, lowering of the reduced nicotinamide-adenine dinucleotide phosphate/oxidized nicotinamide-adenine dinucleotide phosphate ratio and the supply of glutathione to the antioxidant systems, increased levels of reactive oxygen species, peroxidation of spermatozoon membrane lipids, and the consequent generation of acidic degradation products and sequestering of spermine. Acidification of the seminal plasma impairs sperm motility and also inhibits most antioxidant enzymes, exacerbating the accumulation of reactive oxygen species and the resultant lowering of pH.

Original languageEnglish (US)
Pages (from-to)399-401
Number of pages3
JournalFertility and Sterility
Issue number1
StatePublished - Jul 2009
Externally publishedYes


  • Infertility
  • pH
  • reactive oxygen species
  • varicocele

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


Dive into the research topics of 'Hypothesis: intracellular acidification contributes to infertility in varicocele'. Together they form a unique fingerprint.

Cite this