Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats

Zoltán Benyó; Csaba Szabó; Bauke T. Stuiver; Béla Bohus; Péter Sándor

doi:10.1016/0304-3940(95)11981-2

Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats

Zoltán Benyó, Csaba Szabó, Bauke T. Stuiver, Béla Bohus, Péter Sándor

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The effect of the chronic oral application of N^G-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.

Original language	English (US)
Pages (from-to)	127-130
Number of pages	4
Journal	Neuroscience Letters
Volume	198
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(95)11981-2
State	Published - Sep 29 1995
Externally published	Yes

Keywords

Cerebral blood flow
Chronic nitric oxide blockade
Hypertension
Hypothalamus
N-nitro-l-arginine methyl ester
Nitric oxide synthase activity
Rat
Vasoconstriction

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(95)11981-2

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title = "Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats",

abstract = "The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.",

keywords = "Cerebral blood flow, Chronic nitric oxide blockade, Hypertension, Hypothalamus, N-nitro-l-arginine methyl ester, Nitric oxide synthase activity, Rat, Vasoconstriction",

author = "Zolt{\'a}n Beny{\'o} and Csaba Szab{\'o} and Stuiver, {Bauke T.} and B{\'e}la Bohus and P{\'e}ter S{\'a}ndor",

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T1 - Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats

AU - Benyó, Zoltán

AU - Szabó, Csaba

AU - Stuiver, Bauke T.

AU - Bohus, Béla

AU - Sándor, Péter

PY - 1995/9/29

Y1 - 1995/9/29

N2 - The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.

AB - The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.

KW - Cerebral blood flow

KW - Chronic nitric oxide blockade

KW - Hypertension

KW - Hypothalamus

KW - N-nitro-l-arginine methyl ester

KW - Nitric oxide synthase activity

KW - Rat

KW - Vasoconstriction

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AN - SCOPUS:0028875387

SN - 0304-3940

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EP - 130

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats

Abstract

Keywords

ASJC Scopus subject areas

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