Hypertonic saline: First-line therapy for cerebral edema?

Wendy C. Ziai, Thomas J.K. Toung, Anish Bhardwaj

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


This article highlights the experimental and clinical data, controversies and postulated mechanisms surrounding osmotherapy with hypertonic saline (HS) solutions in the neurocritical care arena and builds on previous reviews on the subject. Special attention is focused on HS therapy on commonly encountered clinical paradigms of acute brain injury including traumatic brain injury (TBI), post-operative "retraction edema", intracranial hemorrhage (ICH), tumor-associated cerebral edema, and ischemia associated with ischemic stroke.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - Oct 15 2007
Externally publishedYes


  • Cerebral edema
  • Hypertonic saline
  • Intracranial hemorrhage

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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