TY - JOUR
T1 - Hyperreninemia and hyperaldosteronism in sickle cell anemia
AU - Matustik, M. Cassandra
AU - Carpentieri, Ugo
AU - Corn, Carolyn
AU - Meyer, Walter J.
N1 - Funding Information:
From the Department of Pediatrics of the University of Texas Medical Branch. Supported by Grant RR-73 from the General Clinical Research Centers Program of the Division of Research Resources, National institutes of Health, Public Health Service; and by the Department of Pediatrics, University of Texas Medical Branch and Jeanne B. Kempner Fellowship (M. C. M.). *Reprint address: Division of Endocrinology, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77550.
PY - 1979/8
Y1 - 1979/8
N2 - Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high-and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities and aldosterone secretion rates. The PRA was higher in patients over 10 years of age; ASR in patients receiving the high-sodium diet increased with age. Patients with sickle cell anemia appeared to compensate for urinary sodium loss between crises. The mechanism of this loss could be a defect in the function of either the distal tubule or the loop of Henle.
AB - Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high-and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities and aldosterone secretion rates. The PRA was higher in patients over 10 years of age; ASR in patients receiving the high-sodium diet increased with age. Patients with sickle cell anemia appeared to compensate for urinary sodium loss between crises. The mechanism of this loss could be a defect in the function of either the distal tubule or the loop of Henle.
UR - http://www.scopus.com/inward/record.url?scp=58149411702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149411702&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(79)80652-6
DO - 10.1016/S0022-3476(79)80652-6
M3 - Article
AN - SCOPUS:58149411702
SN - 0022-3476
VL - 95
SP - 197
EP - 201
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 2
ER -