Hyperreninemia and hyperaldosteronism in sickle cell anemia

M. C. Matustik; U. Carpentieri; C. Corn; W. J. Meyer

doi:10.1016/S0022-3476(79)80654-X

Hyperreninemia and hyperaldosteronism in sickle cell anemia

M. C. Matustik, U. Carpentieri, C. Corn, W. J. Meyer

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high- and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities (PRA) and aldosterone secretion rates (ASR). The PRA was higher in patients over 10 years of age; ASR in patients receiving the high-sodium diet increased with age. Patients with sickle cell anemia appeared to compensate for urinary sodium loss between crises. The mechanism of this loss could be a defect in the function of either the distal tubule or the loop of Henle.

Original language	English (US)
Pages (from-to)	206-209
Number of pages	4
Journal	Journal of Pediatrics
Volume	95
Issue number	2
DOIs	https://doi.org/10.1016/S0022-3476(79)80654-X
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Hyperreninemia and hyperaldosteronism in sickle cell anemia",

abstract = "Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high- and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities (PRA) and aldosterone secretion rates (ASR). The PRA was higher in patients over 10 years of age; ASR in patients receiving the high-sodium diet increased with age. Patients with sickle cell anemia appeared to compensate for urinary sodium loss between crises. The mechanism of this loss could be a defect in the function of either the distal tubule or the loop of Henle.",

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AU - Carpentieri, U.

AU - Corn, C.

AU - Meyer, W. J.

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AB - Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high- and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities (PRA) and aldosterone secretion rates (ASR). The PRA was higher in patients over 10 years of age; ASR in patients receiving the high-sodium diet increased with age. Patients with sickle cell anemia appeared to compensate for urinary sodium loss between crises. The mechanism of this loss could be a defect in the function of either the distal tubule or the loop of Henle.

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Hyperreninemia and hyperaldosteronism in sickle cell anemia

Abstract

ASJC Scopus subject areas

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