Human serum Cohn fraction IV (α-globin enriched) inhibits ligand binding at neurotransmitter receptors in human brain

A. C. Andorn; M. A. Pappolla; H. Fox; F. K. Klemens; P. A. Martello

doi:10.1073/pnas.83.12.4572

Human serum Cohn fraction IV (α-globin enriched) inhibits ligand binding at neurotransmitter receptors in human brain

A. C. Andorn, M. A. Pappolla, H. Fox, F. K. Klemens, P. A. Martello

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Human serum proteins are found in significant density in the neuropil in brains of demented individuals. The functional significance of these abnormally distributed proteins has been unknown. We now report that α-globulin-enriched fractions of human serum decrease the specific binding of [³H]spiroperidol at its binding sites in postmortem human frontal cortex and caudate. The substances in this serum fraction apparently exert their effect by a direct action on the binding site. Since [³H]spiroperidol labels serotoninergic and dopaminergic among other neurotransmitter receptors, these results suggest that components of human serum inhibit the binding of ligands at neurotransmitter receptors.

Original language	English (US)
Pages (from-to)	4572-4575
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	83
Issue number	12
DOIs	https://doi.org/10.1073/pnas.83.12.4572
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.83.12.4572

Cite this

@article{c7ccec56acc542c58dfc249b773bf2c4,

title = "Human serum Cohn fraction IV (α-globin enriched) inhibits ligand binding at neurotransmitter receptors in human brain",

abstract = "Human serum proteins are found in significant density in the neuropil in brains of demented individuals. The functional significance of these abnormally distributed proteins has been unknown. We now report that α-globulin-enriched fractions of human serum decrease the specific binding of [3H]spiroperidol at its binding sites in postmortem human frontal cortex and caudate. The substances in this serum fraction apparently exert their effect by a direct action on the binding site. Since [3H]spiroperidol labels serotoninergic and dopaminergic among other neurotransmitter receptors, these results suggest that components of human serum inhibit the binding of ligands at neurotransmitter receptors.",

author = "Andorn, {A. C.} and Pappolla, {M. A.} and H. Fox and Klemens, {F. K.} and Martello, {P. A.}",

year = "1986",

doi = "10.1073/pnas.83.12.4572",

language = "English (US)",

volume = "83",

pages = "4572--4575",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "12",

}

TY - JOUR

T1 - Human serum Cohn fraction IV (α-globin enriched) inhibits ligand binding at neurotransmitter receptors in human brain

AU - Andorn, A. C.

AU - Pappolla, M. A.

AU - Fox, H.

AU - Klemens, F. K.

AU - Martello, P. A.

PY - 1986

Y1 - 1986

N2 - Human serum proteins are found in significant density in the neuropil in brains of demented individuals. The functional significance of these abnormally distributed proteins has been unknown. We now report that α-globulin-enriched fractions of human serum decrease the specific binding of [3H]spiroperidol at its binding sites in postmortem human frontal cortex and caudate. The substances in this serum fraction apparently exert their effect by a direct action on the binding site. Since [3H]spiroperidol labels serotoninergic and dopaminergic among other neurotransmitter receptors, these results suggest that components of human serum inhibit the binding of ligands at neurotransmitter receptors.

AB - Human serum proteins are found in significant density in the neuropil in brains of demented individuals. The functional significance of these abnormally distributed proteins has been unknown. We now report that α-globulin-enriched fractions of human serum decrease the specific binding of [3H]spiroperidol at its binding sites in postmortem human frontal cortex and caudate. The substances in this serum fraction apparently exert their effect by a direct action on the binding site. Since [3H]spiroperidol labels serotoninergic and dopaminergic among other neurotransmitter receptors, these results suggest that components of human serum inhibit the binding of ligands at neurotransmitter receptors.

UR - http://www.scopus.com/inward/record.url?scp=0022547648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022547648&partnerID=8YFLogxK

U2 - 10.1073/pnas.83.12.4572

DO - 10.1073/pnas.83.12.4572

M3 - Article

C2 - 3012573

AN - SCOPUS:0022547648

SN - 0027-8424

VL - 83

SP - 4572

EP - 4575

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 12

ER -

Human serum Cohn fraction IV (α-globin enriched) inhibits ligand binding at neurotransmitter receptors in human brain

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this