Human rickettsioses: Host response and molecular pathogenesis

Casey Schroeder; Imran Chowdhury; Hema Narra; Jignesh Patel; Abha Sahni; Sanjeev Sahni

doi:10.1007/978-3-319-46859-4_19

Human rickettsioses: Host response and molecular pathogenesis

Casey Schroeder, Imran Chowdhury, Hema Narra, Jignesh Patel, Abha Sahni, Sanjeev Sahni

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Rickettsia are medically relevant obligately intracellular bacterial pathogens that cause potentially severe disease. As the causative agents of epidemic typhus and Rocky Mountain spotted fever, these neglected pathogens have had significant impacts on society with mortality rates reaching upwards of 50 %. Antibiotic therapies are often delayed, as initial diagnosis is difficult and easily confused with viral infections. This chapter will address Rickettsia and host interactions such as adhesion to and invasion of host target cells, endothelial pathogenesis, and immune response to rickettsioses. Further, the chapter will provide an overview of rickettsial genetics, metabolism, and secretion systems and their relationship to molecular pathogenesis.

Original language	English (US)
Title of host publication	Rickettsiales
Subtitle of host publication	Biology, Molecular Biology, Epidemiology, and Vaccine Development
Publisher	Springer International Publishing
Pages	399-446
Number of pages	48
ISBN (Electronic)	9783319468594
ISBN (Print)	9783319468570
DOIs	https://doi.org/10.1007/978-3-319-46859-4_19
State	Published - Jan 1 2016

Keywords

Adhesion
Cytokines
Endothelial pathogenesis
Epidemic typhus
Genetics
Innate immunity
Intracellular bacteriaRickettsiaRocky mountain spotted fever
Secretion systems

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

Access to Document

10.1007/978-3-319-46859-4_19

Cite this

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abstract = "Rickettsia are medically relevant obligately intracellular bacterial pathogens that cause potentially severe disease. As the causative agents of epidemic typhus and Rocky Mountain spotted fever, these neglected pathogens have had significant impacts on society with mortality rates reaching upwards of 50 %. Antibiotic therapies are often delayed, as initial diagnosis is difficult and easily confused with viral infections. This chapter will address Rickettsia and host interactions such as adhesion to and invasion of host target cells, endothelial pathogenesis, and immune response to rickettsioses. Further, the chapter will provide an overview of rickettsial genetics, metabolism, and secretion systems and their relationship to molecular pathogenesis.",

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AU - Chowdhury, Imran

AU - Narra, Hema

AU - Patel, Jignesh

AU - Sahni, Abha

AU - Sahni, Sanjeev

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KW - Endothelial pathogenesis

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KW - Secretion systems

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Human rickettsioses: Host response and molecular pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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