TY - JOUR
T1 - Human monocytic and granulocytic ehrlichioses
T2 - Discovery and diagnosis of emerging tick, borne infections and the critical role of the pathologist
AU - Walker, David H.
AU - Dumler, J. Stephen
PY - 1997
Y1 - 1997
N2 - Human monocytic ehrlichiosis and human granulocytic ehrlichiosis are emerging tick-borne infections in the United States. The clinical presentations of these two distinct, potentially life-threatening infections are fever, headache, myalgia, and other diagnostically nonspecific symptoms. Physician awareness is lacking and appropriate diagnostic tests are still not widely available. Because few documented cases have been autopsied, the pathology of human monocytic ehrlichiosis and human granulocytic ehrlichiosis is incompletely described. In human monocytic ehrlichiosis, bone marrow and hepatic granulomas and multiorgan perivascular lymphohistiocytic infiltrates have been observed. In human granulocytic ehrlichiosis, opportunistic fungal and vital infections have been important findings. To expedite an analysis of the pathology and pathogenesis of the human ehrlichioses, it is proposed that a Registry of Pathology of Human Ehrlichioses be established.
AB - Human monocytic ehrlichiosis and human granulocytic ehrlichiosis are emerging tick-borne infections in the United States. The clinical presentations of these two distinct, potentially life-threatening infections are fever, headache, myalgia, and other diagnostically nonspecific symptoms. Physician awareness is lacking and appropriate diagnostic tests are still not widely available. Because few documented cases have been autopsied, the pathology of human monocytic ehrlichiosis and human granulocytic ehrlichiosis is incompletely described. In human monocytic ehrlichiosis, bone marrow and hepatic granulomas and multiorgan perivascular lymphohistiocytic infiltrates have been observed. In human granulocytic ehrlichiosis, opportunistic fungal and vital infections have been important findings. To expedite an analysis of the pathology and pathogenesis of the human ehrlichioses, it is proposed that a Registry of Pathology of Human Ehrlichioses be established.
UR - http://www.scopus.com/inward/record.url?scp=0030829324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030829324&partnerID=8YFLogxK
M3 - Review article
C2 - 9278605
AN - SCOPUS:0030829324
SN - 0003-9985
VL - 121
SP - 785
EP - 791
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 8
ER -